Scientists...have found that the molecule "HNF4A" suppresses pancreatic cancers, regulating both growth and aggressiveness.
Posted by
prayformojo 🐵 (aka mayhem)
Jul 15 '24, 14:41
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Scientists at Nottingham Trent University, the University of Nottingham, Stanford University and the University of California and Cedars-Sinai Medical Center, Los Angeles, have found that the molecule "HNF4A" suppresses pancreatic cancers, regulating both growth and aggressiveness.
Researchers observed that HNF4A was significantly shut down in the very early stages of the cancer, declining further as the disease spread. The study, published in the journal Gastro Hep Advances, could lead to new treatments for the cancer known for its low survival rate. Most are diagnosed late stage when most don't live more than 6 months; of those diagnosed early only 7% live over 5 years.
Dr Maria Hatziapostolou, of Nottingham Trent University’s John van Geest Cancer Research Centre, said: “This work, which has provided new understanding and knowledge of how the cancer behaves, will hopefully help pave the way for potential new treatments in the future.”
She added: “Pancreatic cancer has the lowest survival of all the 20 common cancers. The survival of patients beyond five years has improved very little for some time and so it’s extremely important that we find new ways to better understand this disease, how it spreads and why it is so aggressive.”
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